Author

L. Hedstrom

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Microbiology· 1

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Organism:Arabidopsis· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1

Frequent Co-Authors

D. Close· 1 shared J. K. Michener· 1 shared J. M. Parks· 1 shared N. L. Engle· 1 shared R. J. Giannone· 1 shared S. Cooper· 1 shared T. J. Tschaplinski· 1 shared X. Wang· 1 shared

Activity by Year

2018-2018 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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1 shared paperMicrobiology

D. Close

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1 paper

Recent·Most cited

Horizontal transfer of a pathway for coumarate catabolism unexpectedly inhibits purine nucleotide biosynthesis

D. Close, S. Cooper, X. Wang, R. J. Giannone, N. L. Engle, T. J. Tschaplinski, L. Hedstrom, J. M. Parks, J. K. Michener

The paper shows that horizontal transfer of coumarate catabolism pathways into E. coli requires host mutations to function, as intermediates inhibit purine biosynthesis, and some mutations are already present in the native host.

bioRxiv · May 4, 2018Microbiology