Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
B. Russell Lewis, M. R. Uddin, M. Moniruzzaman, K. M. Kuo, A. J. Higgins, L. M. N. Shah, F. Sobott, J. M. Parks, D. Hammerschmid, J. C. Gumbart, H. I. Zgurskaya, E. Reading
The paper investigates how an inhibitor restricts the conformational dynamics of AcrA, a multidrug efflux adaptor protein, to block drug signal transmission in E. coli.
bioRxiv · Dec 9, 2022Biochemistry
C. M. Gionfriddo, A. Soren, A. M. Wymore, D. S. Hartnett, M. Podar, J. M. Parks, D. A. Elias, C. C. Gilmour
This paper investigates the transcriptional regulation of hgcAB by an ArsR-like regulator in Pseudodesulfovibrio mercurii ND132, revealing its link to arsenic resistance and mercury methylation.
bioRxiv · Oct 17, 2022 · PreprintMicrobiology
D. Pal, K. De, C. M. Shanks, K. Feng, T. B. Yates, J. Morrell-Falvey, R. B. Davidson, J. M. Parks, W. Muchero
This study identifies core cysteine residues in the PAN domain of HGF as essential for c-MET signaling, showing their role in receptor binding, phosphorylation, and downstream gene activation.
bioRxiv · Sep 20, 2021 · PreprintCell Biology
A. Pavlova, Z. Zhang, A. Acharya, D. L. Lynch, Y. T. Pang, Z. Mou, J. M. Parks, C. Chipot, J. C. Gumbart
This study identifies critical residues for SARS-CoV-2 spike protein binding to ACE2 using machine learning and free energy calculations, showing how specific mutations affect binding affinity.
bioRxiv · Mar 19, 2021Biophysics
A. Pavlova, D. L. Lynch, I. Daidone, L. Zanetti-Polzi, M. D. Smith, C. Chipot, D. W. Kneller, A. Kovalevsky, L. Coates, A. A. Golosov, C. J. Dickson, C. Velez-Vega, J. S. Duca, J. V. Vermaas, Y. T. Pang, , J. C. Gumbart
This study uses molecular dynamics simulations to investigate how inhibitor binding affects the protonation states of histidines in SARS-CoV-2 main protease, showing their impact on structural stability and inhibitor binding.
bioRxiv · Sep 7, 2020Biophysics
R. Ajina, A. Zuo, S. Wang, M. Moussa, C. J. Cooper, Y. Shen, Q. R. Johnson, J. M. Parks, J. C. Smith, M. Catalfamo, E. J. Fertig, S. A. Jablonski, L. M. Weiner
This study shows immune selection pressure in pancreatic cancer drives myeloid mimicry and immune evasion, which can be counteracted by JAK/STAT pathway inhibition to enhance immunotherapy.
bioRxiv · Jun 15, 2020 · PreprintCancer Biology
S. S. Date, J. M. Parks, K. W. Rush, J. D. Wall, S. W. Ragsdale, A. Johs
This study reports the kinetics of HgcAB-mediated mercury methylation at nanomolar concentrations, showing high oxygen sensitivity and Michaelis-Menten kinetics with specific KM and Vmax values.
bioRxiv · Jan 4, 2019Biochemistry
D. Close, S. Cooper, X. Wang, R. J. Giannone, N. L. Engle, T. J. Tschaplinski, L. Hedstrom, J. M. Parks, J. K. Michener
The paper shows that horizontal transfer of coumarate catabolism pathways into E. coli requires host mutations to function, as intermediates inhibit purine biosynthesis, and some mutations are already present in the native host.
bioRxiv · May 4, 2018Microbiology