Author

L. J. Bridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

S. R. J. Hoare· 2 shared A. M. Quinn· 1 shared D. A. Hall· 1 shared P. H. Tewson· 1 shared T. E. Hughes· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 7 mutual co-author links

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2 shared papersPharmacology & Toxicology

S. R. J. Hoare

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2 papers

Recent·Most cited

Analyzing kinetic signaling data for G-protein-coupled receptors

S. R. J. Hoare, P. H. Tewson, A. M. Quinn, T. E. Hughes, L. J. Bridge

This study applies empirical and mechanistic modeling to kinetic signaling data of G-protein-coupled receptors to quantify signaling efficacy and regulation parameters.

bioRxiv · Jan 20, 2020Pharmacology & Toxicology

A kinetic operational model of agonism incorporating receptor desensitization for G-protein-coupled receptors

S. R. J. Hoare, D. A. Hall, L. J. Bridge

This paper introduces a kinetic model for drug efficacy that incorporates receptor desensitization and response degradation, enabling independent measurement of drug effect and regulation parameters.

bioRxiv · Sep 9, 2019 · PreprintPharmacology & Toxicology