T. E. Hughes

Mutations in NAKED-ENDOSPERM IDD genes reveal functional interactions with SCARECROW and a maternal influence on leaf patterning in C4 grasses

The paper shows that mutations in NKD IDD genes worsen leaf patterning defects in C4 grasses but not C3 grasses, and identifies a maternal influence on leaf cell patterning during embryogenesis.

SCARECROW is deployed in distinct developmental contexts during rice and maize leaf development

The study shows that SCARECROW regulates stomatal development in rice and inner leaf patterning in maize, indicating divergent developmental roles after speciation.

SCARECROW gene function is required for photosynthetic development in maize

This study shows that maize SCARECROW genes are essential for photosynthetic development, as their mutation reduces chlorophyll content and photosynthetic enzyme activity, affecting plant growth.

Analyzing kinetic signaling data for G-protein-coupled receptors

This study applies empirical and mechanistic modeling to kinetic signaling data of G-protein-coupled receptors to quantify signaling efficacy and regulation parameters.

A new kinetic method for measuring agonist efficacy and ligand bias using high resolution biosensors and a kinetic data analysis framework

The paper introduces a kinetic method using biosensors and analysis framework to measure agonist efficacy and ligand bias by quantifying arrestin recruitment kinetics.

Redundant SCARECROW genes pattern distinct cell layers in roots and leaves of maize

This study shows that two redundant maize SCARECROW genes regulate mesophyll and endodermal cell layer patterning in leaves and roots, respectively.

Understanding the Ca2+-dependent Fluorescence Change in Red Genetically Encoded Ca2+ Indicators

The paper analyzes nine red GECIs to determine the factors causing Ca2+-dependent fluorescence changes, finding three distinct classes based on their mechanisms.

A genetically encoded Ca2+ indicator based on circularly permutated sea anemone red fluorescent protein

The paper develops and validates a new red fluorescent calcium indicator, K-GECO1, based on a circularly permutated RFP from a sea anemone, tested across multiple cell types and organisms.