Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
S. R. J. Hoare, P. H. Tewson, A. M. Quinn…·L. J. Bridge
This study applies empirical and mechanistic modeling to kinetic signaling data of G-protein-coupled receptors to quantify signaling efficacy and regulation parameters.
S. R. J. Hoare, P. H. Tewson, A. M. Quinn, T. E. Hughes
The paper introduces a kinetic method using biosensors and analysis framework to measure agonist efficacy and ligand bias by quantifying arrestin recruitment kinetics.
S. R. J. Hoare, D. A. Hall, L. J. Bridge
This paper introduces a kinetic model for drug efficacy that incorporates receptor desensitization and response degradation, enabling independent measurement of drug effect and regulation parameters.