Inhibiting adenine synthesis attenuates glioblastoma cell stemness and temozolomide resistance
S. X. Singh, R. Yang, K. Roso, L. J. Hansen, C. Du, L. H. Chen, P. K. Greer, C. J. Pirozzi, Y. He
This study shows that inhibiting adenine synthesis with L-Alanosine reduces stemness and temozolomide resistance in MTAP-deficient glioblastoma cells by impairing mitochondrial function.
bioRxiv · Jun 21, 2021 · PreprintCancer Biology