L. H. Chen

HIGH THROUGHPUT QUANTITATION OF HUMAN NEUTROPHIL RECRUITMENT AND FUNCTIONAL RESPONSES IN AN AIR-BLOOD BARRIER ARRAY

The paper develops a high-throughput assay to study neutrophil recruitment and function in an air-blood barrier array, showing improved throughput and sample efficiency compared to existing methods.

Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma

The paper identifies tumor-specific alternative splicing events in glioma that could generate cell-surface antigens but finds significant spatiotemporal heterogeneity and lack of proteomic evidence.

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens

The paper identifies tumor-wide splicing aberrations that generate public neoantigens, enabling T-cell-based immunotherapies targeting intratumoral heterogeneity.

Repurposing clemastine to target glioblastoma cell stemness

This study shows clemastine, an antihistamine, reduces glioblastoma stemness by targeting EBP, a cholesterol pathway enzyme, and promotes differentiation of oligodendrocyte progenitor cells.

Aeromonas hydrophila induces skin disturbance through mucosal microbiota dysbiosis in Pangasianodon hypophthalmus

This study investigates how Aeromonas hydrophila affects the skin mucosal microbiota and immune response in striped catfish, finding that pathogen-induced dysbiosis triggers immune stimulation.

Focal adhesion membrane is dotted with protein islands and partitioned for molecular hop diffusion

The paper demonstrates that focal adhesion membrane is partitioned into compartments where molecules undergo hop diffusion, with protein islands acting as dynamic hubs for integrin interactions.

Inhibiting adenine synthesis attenuates glioblastoma cell stemness and temozolomide resistance

This study shows that inhibiting adenine synthesis with L-Alanosine reduces stemness and temozolomide resistance in MTAP-deficient glioblastoma cells by impairing mitochondrial function.

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia

This study uses STIP-Seq to analyze HIV-1 reservoirs and identifies proviral features and cellular sources contributing to plasma viremia in ART-suppressed individuals.

Tumor-specific changes in Kaposi sarcoma-associated herpesvirus genomes in Ugandan adults with Kaposi sarcoma

This study analyzes KSHV genome variability in Ugandan HIV-associated KS patients, finding high homogeneity within individuals but tumor-specific mutations and inactivations.