Genome-wide screen of Mycobacterium tuberculosis-infected macrophages identified the GID/CTLH complex as a determinant of intracellular bacterial growth.
N. V. Simwela, L. Johnston, P. Pavinski Bitar, E. Jaecklein, C. Altier, C. M. Sassetti, D. G. Russell
The paper identifies the GID/CTLH complex as a host determinant suppressing antimicrobial responses against intracellular bacterial infections through a CRISPR screen in Mtb-infected macrophages.
bioRxiv · May 6, 2024 · PreprintImmunology