Author

E. Jaecklein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

C. M. Sassetti· 3 shared N. V. Simwela· 2 shared A. J. C. Steyn· 1 shared A. J. Olive· 1 shared C. Altier· 1 shared D. G. M. Russell· 1 shared D. G. Russell· 1 shared J. Mackenzie· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMicrobiology

C. M. Sassetti

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis

N. V. Simwela, E. Jaecklein, C. M. Sassetti, D. G. M. Russell

This study shows that impaired macrophage fatty acid metabolism limits Mycobacterium tuberculosis growth through multiple anti-microbial mechanisms.

bioRxiv · Jul 22, 2024Microbiology

Genome-wide screen of Mycobacterium tuberculosis-infected macrophages identified the GID/CTLH complex as a determinant of intracellular bacterial growth.

N. V. Simwela, L. Johnston, P. Pavinski Bitar, E. Jaecklein, C. Altier, C. M. Sassetti, D. G. Russell

The paper identifies the GID/CTLH complex as a host determinant suppressing antimicrobial responses against intracellular bacterial infections through a CRISPR screen in Mtb-infected macrophages.

bioRxiv · May 6, 2024 · PreprintImmunology

Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase

Y. Cai, E. Jaecklein, J. Mackenzie, K. Papavinasasundaram, A. J. Olive, X. Chen, A. J. C. Steyn, C. M. Sassetti

This study shows that Mycobacterium tuberculosis relies on cytochrome bd oxidase to resist the adaptive immune response, particularly under acidic conditions in macrophages.

bioRxiv · Aug 21, 2020Microbiology