Author

N. V. Simwela

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Organism:plant (other)· 1

Frequent Co-Authors

A. P. Waters· 4 shared M. P. Barrett· 3 shared M. T. Rennie· 2 shared A. B. Roberts· 1 shared A. W. Guiguemde· 1 shared B. H. Stokes· 1 shared B. Taft· 1 shared C. Regnault· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersMicrobiology

A. P. Waters

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A conserved metabolic signature associated with response to fast-acting antimalarial agents

N. V. Simwela, A. W. Guiguemde, J. Straimer, C. Regnault, F. Yokokawa, B. Taft, T. T. Diagana, M. P. Barrett, A. P. Waters

This paper identifies a conserved metabolic signature in malaria parasites exposed to fast-acting antimalarial drugs, suggesting a common mechanism of action.

bioRxiv · Oct 3, 2022 · PreprintMicrobiology

Plasmodium berghei K13 Mutations Mediate In Vivo Artemisinin Resistance That is Reversed by Proteasome Inhibition

N. V. Simwela, B. H. Stokes, D. Aghabi, M. Bogyo, D. A. Fidock, A. P. Waters

This study introduces K13 mutations into Plasmodium berghei to demonstrate their role in mediating artemisinin resistance in vivo, showing delayed parasite clearance and synergistic effects with proteasome inhibitors.

mBio · Dec 22, 2020Peer-reviewedMicrobiology

Mammalian deubiquitinating enzyme inhibitors display in vitro and in vivo activity against malaria parasites and potentiate artemisinin action

N. V. Simwela, K. R. P. Hughes, M. T. Rennie, M. P. Barrett, A. P. Waters

This paper shows that mammalian deubiquitinating enzyme inhibitors inhibit malaria parasites in vitro and in vivo, and enhance artemisinin activity, offering a strategy to combat artemisinin resistance.

bioRxiv · Aug 13, 2020Microbiology

Experimentally engineered mutations in a ubiquitin hydrolase, UBP-1, modulate in vivo resistance to artemisinin and chloroquine in Plasmodium berghei.

N. V. Simwela, K. R. Hughes, A. B. Roberts, M. T. Rennie, M. P. Barrett, A. P. Waters

This study experimentally tests mutations in UBP-1 in Plasmodium berghei and shows they confer resistance to artemisinin and chloroquine.

bioRxiv · Dec 12, 2019Microbiology