Author

L. Khemtemourian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

B. O. W. Elenbaas· 2 shared J. A. Killian· 2 shared S. Lecomte· 2 shared T. Sinnige· 2 shared A. Vial· 1 shared B. Davion· 1 shared B. Strodel· 1 shared C. Feuillie· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

B. O. W. Elenbaas

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

N-formylation modifies membrane damage associated to PSMα3 interfacial fibrillation

L. Bonnecaze, K. Jumel, A. Vial, L. Khemtemourian, C. Feuillie, M. Molinari, S. Lecomte, M. Mathelie-Guinlet

This study shows N-formylation of PSM3 affects its membrane interactions and self-assembly, leading to membrane damage through intermediate protofibrillar entities.

bioRxiv · Feb 27, 2024Biophysics

Fibril elongation by human islet amyloid polypeptide is the main event linking aggregation to membrane damage

B. O. W. Elenbaas, S. M. Kremsreiter, L. Khemtemourian, J. A. Killian, T. Sinnige

This study investigates how hIAPP aggregation relates to membrane damage, finding that fibril elongation, not oligomers, is the main cause of vesicle leakage.

bioRxiv · Oct 14, 2022Biochemistry

Membrane-catalyzed aggregation of islet amyloid polypeptide is dominated by secondary nucleation

B. O. W. Elenbaas, L. Khemtemourian, J. A. Killian, T. Sinnige

This study investigates IAPP aggregation on lipid membranes, finding that secondary nucleation dominates the process, with anionic lipids promoting both primary and secondary nucleation but not elongation.

bioRxiv · Feb 4, 2022Biophysics

Structural dissection of the first events following membrane binding of the islet amyloid polypeptide

L. Khemtemourian, H. Fatafta, B. Davion, S. Lecomte, S. Castano, B. Strodel

This study investigates the early molecular events of IAPP binding to lipid membranes using spectroscopy, microscopy, and simulations, revealing how residue 18 affects structure and aggregation.

bioRxiv · Dec 14, 2021Biophysics