Author

L. Kiefer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

J. T. Zimmer· 2 shared M. D. Simon· 2 shared A. E. Barentine· 1 shared A. Patel· 1 shared A. Qin· 1 shared E. Courchaine· 1 shared G. Biancon· 1 shared G. Viero· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiochemistry

J. T. Zimmer

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2 papers

Recent·Most cited

Improving the study of RNA dynamics through advances in RNA-seq with metabolic labeling and nucleotide-recoding chemistry

J. T. Zimmer, I. W. Vock, J. A. Schofield, L. Kiefer, M. H. Moon, M. D. Simon

This paper identifies and mitigates dropout in RNA metabolic labeling and NR-seq experiments through optimized protocols and improved alignment pipelines.

bioRxiv · May 24, 2023 · PreprintBiochemistry

Multi-omics profiling of U2AF1 mutants dissects pathogenic mechanisms affecting RNA granules in myeloid malignancies

G. Biancon, P. Joshi, J. T. Zimmer, T. Hunck, Y. Gao, M. D. Lessard, E. Courchaine, A. E. Barentine, M. Machyna, V. Botti, A. Qin, R. Gbyli, A. Patel, Y. Song, L. Kiefer, , S. Halene

This study uses multi-omics profiling to analyze U2AF1 mutations in myeloid malignancies, revealing altered RNA binding, splicing, and stress granule formation.

bioRxiv · Apr 22, 2021Cancer Biology