Author

R. Gbyli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

S. Halene· 3 shared Y. Song· 3 shared T. Tebaldi· 2 shared A. Bagale· 1 shared A. E. Barentine· 1 shared A. Patel· 1 shared A. Qin· 1 shared A. Rongvaux· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

S. Halene

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Multi-omics profiling of U2AF1 mutants dissects pathogenic mechanisms affecting RNA granules in myeloid malignancies

G. Biancon, P. Joshi, J. T. Zimmer, T. Hunck, Y. Gao, M. D. Lessard, E. Courchaine, A. E. Barentine, M. Machyna, V. Botti, A. Qin, R. Gbyli, A. Patel, Y. Song, L. Kiefer, , S. Halene

This study uses multi-omics profiling to analyze U2AF1 mutations in myeloid malignancies, revealing altered RNA binding, splicing, and stress granule formation.

bioRxiv · Apr 22, 2021Cancer Biology

MCL1 dependence across MDS subtypes and dual inhibition of MCL1 and BCL2 in MISTRG6 mice

M. A. Fischer, Y. Song, R. Gbyli, M. P. Arrate, M. T. Villaume, M. A. Childress, B. N. Smith, T. P. Stricker, S. Halene, M. R. Savona

The paper assesses MCL1 dependence in MDS subtypes and shows that combined inhibition of BCL2 and MCL1 is synergistic in vitro and reduces MDS engraftment in mice.

bioRxiv · Jun 5, 2020 · PreprintCancer Biology

A Highly Efficient and Faithful MDS Patient-Derived Xenotransplantation Model for Pre-Clinical Studies

Y. Song, A. Rongvaux, A. Taylor, T. Jiang, T. Tebaldi, K. Balasubramanian, A. Bagale, Y. K. Terzi, R. Gbyli, X. Wang, J. Zhao, N. Podoltsev, M. Xu, N. Neparidze, E. Wong, , S. Halene

This paper develops a novel MDS patient-derived xenotransplantation model in MISTRG mice that faithfully represents all MDS subtypes and enables effective drug testing.

bioRxiv · Feb 14, 2018Cancer Biology