Author

L. Kuhlen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 4 Approach:experimental assay· 4 Assay:cryo-EM· 3 Research Focus:protein structure prediction· 3 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

J. Deme· 4 shared S. Johnson· 4 shared S. Lea· 2 shared S. M. Lea· 2 shared A. Zeitler· 1 shared E. Furlong· 1 shared J. Fisher· 1 shared J. Y. Cao· 1 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersMicrobiology

J. Deme

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4 papers

Recent·Most cited

Nonameric structures of the cytoplasmic domain of FlhA and SctV in the context of the full-length protein

L. Kuhlen, S. Johnson, J. Y. Cao, J. Deme, S. M. Lea

The paper determines the structure of the nonameric cytoplasmic domains of FlhA and SctV using cryo-EM, revealing a conserved interaction stabilizing the ring assembly.

bioRxiv · Oct 12, 2020Microbiology

Structure of the bacterial flagellar rotor MS-ring: a minimum inventory/maximum diversity system

S. Johnson, Y. H. Fong, J. Deme, E. Furlong, L. Kuhlen, S. Lea

This study presents the structure of the Salmonella MS-ring, revealing symmetry variation that explains its role in flagellar function.

bioRxiv · Jul 30, 2019 · PreprintMicrobiology

The flagellar substrate specificity switch protein FlhB assembles onto the extra-membrane export gate to regulate type three secretion

L. Kuhlen, S. Johnson, A. Zeitler, S. Baurle, J. Deme, R. Debo, J. Fisher, S. Wagner, S. Lea

The paper determines the structure of the FlhB/SctU switch protein in the type three secretion system export gate and shows its role in regulating secretion specificity.

bioRxiv · Jul 4, 2019 · PreprintMicrobiology

The structure of an injectisome export gate demonstratesconservation of architecture in the core export gatebetween flagellar and virulence type three secretionsystems

S. Johnson, L. Kuhlen, J. Deme, P. Abrusci, S. M. Lea

The paper presents the structure of a T3SS export gate complex from Shigella at 3.5 Å resolution, confirming structural conservation with the flagellar system.

bioRxiv · Mar 27, 2019Biochemistry