S. Wagner

DeePosit: an AI-based tool for detecting mouse urine and fecal depositions from thermal video clips of behavioral experiments

DeePosit detects and classifies urine and fecal deposits in mice from thermal videos, showing distinct dynamics in test, strain, and sex contexts.

Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity

The paper identifies a synthetic small molecule, C26, that inhibits HilD, a key regulator of Salmonella secretion systems, thereby preventing bacterial invasion of host cells.

The T4bSS of Legionella features a two-step secretion pathway with an inner membrane intermediate for secretion of transmembrane effectors

This study investigates the secretion mechanism of transmembrane effector proteins by Legionella T4bSS, revealing a two-step process involving an inner membrane intermediate.

Whole-genome screening for near-diagnostic genetic markers for white oak species identification in Europe

The paper identifies near-diagnostic SNPs for four white oak species using whole-genome data to aid in species identification in Europe.

ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

This study shows ATF6 activation in colonic epithelial cells alters lipid metabolism, promoting tumor-associated microbial adaptation in mice and human colorectal cancer patients.

Simultaneous recording of ultrasonic vocalizations and sniffing from socially interacting individual rats using a miniature microphone

This paper introduces a miniature microphone to record individual rat vocalizations and sniffing during social interactions, revealing new vocalization types and distinct internal state dynamics.

Localization of four class I glutaredoxins in the cytosol and the secretory pathway and characterization of their biochemical diversification

The paper identifies the subcellular localization and biochemical properties of four class I glutaredoxins in Arabidopsis, showing distinct redox activities and membrane associations.

Altered iron-sulfur cluster transfer in Arabidopsis mitochondria reveals lipoyl synthase as a Janus-faced enzyme that generates toxic sulfide

The paper shows that altered iron-sulfur cluster transfer in Arabidopsis mitochondria leads to toxic sulfide release by lipoyl synthase, affecting plant growth and sulfide homeostasis.

HilE represses the activity of HilD via a mechanism distinct from that of intestinal long-chain fatty acids.

This study identifies two distinct mechanisms by which HilD activity is repressed: LCFAs bind to a conserved pocket, while HilE forms a heterodimer with HilD.

Indolent primary cutaneous B-cell lymphomas resemble persistent antigen reactions without signs of dedifferentiation

This study uses single-cell RNA sequencing to compare indolent primary cutaneous B-cell lymphomas with other B-cell proliferations, finding they resemble persistent antigen reactions with germinal center features.

Dissecting the invasion of Galleria mellonella by Yersinia enterocolitica reveals metabolic adaptations and a role of a phage lysis cassette in insect killing

This study investigates Yersinia enterocolitica's infection of Galleria mellonella larvae, identifying metabolic adaptations and a role for a phage lysis cassette in insect killing.

Bartonella taylorii: A model organism for studying Bartonella infection in vitro and in vivo

This paper introduces B. taylorii as a new model organism for studying Bartonella infection, showing improved in vitro and in vivo infectivity under specific growth conditions.

Sex-dependent parameters of social behavior show marked variations between distinct laboratory mouse strains and their mixed offspring

The paper examines sex- and strain-specific variations in social behavior among laboratory mice and their mixed offspring, revealing genetic influences on social preference tests.

Clonal reconstruction from co-occurrence of vector integration sites allows accurate quantification of expanding clones in vivo

This paper quantifies expanding clones in vivo by reconstructing clonal origins from integration site co-occurrence, improving safety assessment in gene therapy.

Uncovering the Bromodomain Interactome using Site-Specific Azide-Acetyllysine Photochemistry, Proteomic Profiling and Structural Characterization

This study maps the bromodomain interactome using chemoproteomic methods, revealing new interactions and structural insights into BET protein function.

MBNL1 and RBFOX1 co-regulate alternative splicing events transcriptome-wide through a conserved buffering mechanism

This study identifies a conserved buffering mechanism where MBNL1 and RBFOX1 co-regulate alternative splicing by overlapping RNA motifs, reducing the range of splicing outcomes.

Sensitizing Staphylococcus aureus to antibacterial host defense by decoding and blocking the lipid flippase MprF

This study develops MprF-targeting monoclonal antibodies that block the lipid flippase MprF, increasing MRSA susceptibility to antimicrobial peptides and antibiotics.

Photosynthetic activity triggers pH and NAD redox signatures across different plant cell compartments

The paper investigates how photosynthetic activity affects subcellular pH and NAD redox status in Arabidopsis cells using fluorescent biosensors.

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity

The paper shows BTK modulates NLRP3 inflammasome activity through phosphorylation of tyrosine residues, affecting localization, oligomerization, and IL-1β release.

Social recognition in rats and mice requires integration of olfactory, somatosensory and auditory cues

This study shows that social recognition in rats and mice requires integration of olfactory, somatosensory, and auditory cues, unlike humans who rely on a single modality.

Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation reveals multisite regulation of surface expression and gating

The paper identifies 42 phosphorylation sites on NaV1.5 channels in mouse hearts and shows their roles in regulating channel expression and gating.

Branched-chain amino acid catabolism depends on GRXS15 through mitochondrial lipoyl cofactor homeostasis

The paper shows that GRXS15 deficiency disrupts mitochondrial lipoyl cofactor homeostasis, leading to metabolic defects in lipoyl cofactor-dependent dehydrogenase complexes, particularly affecting branched-chain amino acid catabolism.

APOBEC3A Catalyzes Mutation and Drives Carcinogenesis In Vivo

This study shows APOBEC3A promotes tumorigenesis in mice and supports its role in causing mutations in human cancers.

A NanoLuc luciferase-based assay enabling the real-time analysis of protein secretion and injection by bacterial type III secretion systems

This paper develops a NanoLuc luciferase-based assay to quantitatively monitor bacterial type III secretion and injection of effector proteins into host cells.

The flagellar substrate specificity switch protein FlhB assembles onto the extra-membrane export gate to regulate type three secretion

The paper determines the structure of the FlhB/SctU switch protein in the type three secretion system export gate and shows its role in regulating secretion specificity.

Preserving cultural heritage: Analyzing the antifungal potential of ionic liquids tested in paper restoration

This study evaluates four ionic liquids for antifungal activity in paper restoration, finding that all inhibit fungal growth, with potency increasing with non-polar group size.

Redox-mediated Kick-Start of Mitochondrial Energy Metabolism drives Resource-efficient Seed Germination

The paper identifies redox-mediated activation of mitochondrial energy metabolism as critical for efficient seed germination in Arabidopsis.

TrackUSF, a novel methodology for automated analysis of ultrasonic vocalizations, reveals modified social communication in a rat model of autism

TrackUSF automates USV analysis, revealing altered social communication in Shank3-deficient rats.

ATP sensing in living plant cells reveals tissue gradients and stress dynamics of energy physiology

The paper develops a fluorescent biosensor to measure MgATP2- dynamics in living plant cells, revealing tissue-specific gradients and stress responses in ATP homeostasis.

Resolving Drug Effects In Patient-Derived Cancer Cells Links Organoid Responses To Genome Alterations

The paper compares drug responses in ovarian cancer organoids and monolayer cultures, finding differences in drug efficacy and genomic associations.