PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK
E. Cho, H. J. Lou, L. Kuruvilla, D. A. Calderwood, B. E. E. Turk
This study identifies PPP6C as a MEK phosphatase that negatively regulates ERK signaling by dephosphorylation, with implications for melanoma therapy resistance.
bioRxiv · Sep 18, 2020Cancer Biology