Fascin-induced bundling protects actin filaments from disassembly by cofilin
J. Chikireddy, L. Lengagne, R. Le Borgne, H. Wioland, G. Romet-Lemonne, A. Jegou
This study shows that fascin crosslinking slows cofilin-induced actin filament disassembly by reducing cofilin cluster nucleation on bundles, while promoting inter-filament cooperativity.
bioRxiv · May 19, 2023Biochemistry