Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment
C. Danis, E. Dupre, O. Zejneli, R. Caillierez, A. Arrial, S. Begard, A. Loyens, J. Mortelecque, F.-X. Cantrelle, X. Hanoulle, J.-C. Rain, M. Colin, L. Luc Buee, I. Landrieu
This study identifies and optimizes a single domain antibody fragment that inhibits Tau aggregation in vitro and in a mouse model of tauopathy.
bioRxiv · Mar 23, 2021Biochemistry