J.-C. Rain

Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein

The paper optimizes VHH antibodies targeting Tau's PHF6 peptide through mutagenesis and screening, showing improved binding and aggregation inhibition, but also highlighting the importance of stability beyond affinity.

Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment

This study identifies and optimizes a single domain antibody fragment that inhibits Tau aggregation in vitro and in a mouse model of tauopathy.