PARP and PI3K inhibitor combination therapy eradicates c-MYC-driven murine prostate cancers via cGAS/STING pathway activation within tumor-associated macrophages
P. D. Gupta, K. Chaudagar, S. Sharma-Saha, K. M. Bynoe, L. Maillat, B. Heiss, W. Stadler, A. Patnaik
This paper shows that combining PARP and PI3K inhibitors eradicates c-MYC-driven prostate cancer by activating the cGAS/STING pathway in tumor-associated macrophages.
bioRxiv · Jul 17, 2020 · PreprintCancer Biology