S. Sharma-Saha

BET inhibition sensitizes immunologically-cold Rb-deficient prostate cancer to immune checkpoint blockade

This paper shows that BET inhibition makes immunologically cold Rb-deficient prostate cancer more responsive to immune checkpoint blockade by reprogramming the tumor microenvironment through STING/NF-κB/IFN signaling.

PARP and PI3K inhibitor combination therapy eradicates c-MYC-driven murine prostate cancers via cGAS/STING pathway activation within tumor-associated macrophages

This paper shows that combining PARP and PI3K inhibitors eradicates c-MYC-driven prostate cancer by activating the cGAS/STING pathway in tumor-associated macrophages.