Author

L. Nel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:yeast· 2 Assay:cryo-EM· 1 Assay:structural biology· 1

Frequent Co-Authors

B. P. Pedersen· 2 shared E. Olesen· 2 shared K. M. Frain· 2 shared A. Bohush· 1 shared D. Hoeglinger· 1 shared D. Jamecna· 1 shared D. L. Stokes· 1 shared D. Wustner· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

B. P. Pedersen

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2 papers

Recent·Most cited

Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C1-related protein

L. Nel, K. Thaysen, D. Jamecna, E. Olesen, M. Szomek, J. Langer, K. M. Frain, D. Hoeglinger, D. Wustner, B. P. Pedersen

This study investigates the lipid binding properties of the yeast NCR1/NPC2 system using crystal structures and binding assays, revealing its ability to bind multiple lipids beyond sterols.

bioRxiv · Jun 10, 2024Biophysics

Conformational changes in the Niemann-Pick Type C1 protein NCR1 drive sterol translocation

K. M. Frain, E. Dedic, L. Nel, A. Bohush, E. Olesen, D. L. Stokes, B. P. Pedersen

This study identifies a glycocalyx in yeast vacuoles and presents cryo-EM structures of NCR1 showing conformational changes that drive sterol translocation across the glycocalyx.

bioRxiv · Sep 8, 2023Biochemistry