Mechanistic insights into robust cardiac IKs potassium channel activation by aromatic polyunsaturated fatty acid analogues
B. M. Bohannon, J. J. Jowais, L. Nyberg, S. I. Liin, H. P. Larsson
The paper identifies aromatic PUFA analogues that activate the cardiac IKs channel through hydrogen bonding and ionic interactions, not cation-pi interactions.
bioRxiv · Jan 12, 2023Physiology