J. J. Jowais

PUFA stabilizes a conductive state of the selectivity filter in IKs channels

This study investigates how PUFAs stabilize the selectivity filter of IKs channels, increasing their conductance and potentially treating Long QT Syndrome.

Mechanistic insights into robust cardiac IKs potassium channel activation by aromatic polyunsaturated fatty acid analogues

The paper identifies aromatic PUFA analogues that activate the cardiac IKs channel through hydrogen bonding and ionic interactions, not cation-pi interactions.