27-hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor
S. Ayadi, S. Friedrichs, R. Soules, L. Pucheu, D. Luetjohann, S. Silvente-Poirot, M. Poirot, P. de Medina
The paper shows that CYP27A1 converts OCDO into 27H-OCDO, which inhibits breast cancer cell proliferation, switching its activity from pro-tumor to anti-tumor.
bioRxiv · Oct 10, 2023 · PreprintBiochemistry