Author

D. Luetjohann

University Hospital Bonn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Alaa OthmaniD· 1 shared Amartya SinghiD· 1 shared Anja KerksiekiD· 1 shared Anthony K. ShumiD· 1 shared Antoine RimbertiD· 1 shared Arnold von EckardsteiniD· 1 shared Bart van de SluisiD· 1 shared Brian WoodsiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCell Biology

Alaa OthmanORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The COPI coatomer influences LDL receptor activity, hepatic lipid storage, and apoB secretion

Grigorios Panteloglou, Jérôme Robert, Marieke Smit, Nicolette Huijkman, Niels Kloosterhuis, Christopher S. Law, Brian Woods, Alaa Othman, Marcus Edi Kleber, Graciela Delgado, Patrizia Tarugi, Museer A. Lone, Justina Clarinda Wolters, Antoine Rimbert, Anja Kerksiek, , Arnold von Eckardstein

This study identifies COPI coatomer subunits that regulate LDL receptor activity, apoB secretion, and hepatic lipid storage, with genetic variants linked to elevated LDL-C levels.

Atherosclerosis · Aug 25, 2026Peer-reviewedCell Biology

A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL

Komal Mandleywala, Simona Ulrich, Victoria da Silva-Diz, Puneet Sharma, Christopher Thai, Oekyung Kim, Maya Aleksandrova, Gwendolyn Chung, Cristián Eggers, D. Luetjohann, Tanaya Kulkarni, Amartya Singh, M. Elena Díaz-Rubio, Michael Wierer, Sebastian A. Leidel, , Daniel Herranz

This study identifies histidine depletion as an antileukemic strategy in T-ALL by revealing its role in suppressing cholesterol biosynthesis through ribosome stalling and GCN2 activation.

bioRxiv · Dec 23, 2025 · PreprintCancer Biology

27-hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor

S. Ayadi, S. Friedrichs, R. Soules, L. Pucheu, D. Luetjohann, S. Silvente-Poirot, M. Poirot, P. de Medina

The paper shows that CYP27A1 converts OCDO into 27H-OCDO, which inhibits breast cancer cell proliferation, switching its activity from pro-tumor to anti-tumor.

bioRxiv · Oct 10, 2023 · PreprintBiochemistry