PhysiologybioRxivPreprint
GCN5L1 promotes diastolic dysfunction by inhibiting cardiac pyruvate oxidation
D. Thapa, P. Bugga, B. A. S. Mushala…·I. Scott
This study identifies GCN5L1 as a regulator of cardiac pyruvate oxidation, showing its role in promoting diastolic dysfunction through inhibition of PDH complex acetylation in aged obese mice.
DOI 10.1101/2021.09.07.459319