Author

B. McMahon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biochemistry· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

I. Scott· 2 shared P. Bugga· 2 shared A. Lappala· 1 shared A. Lohar· 1 shared A. R. Matuszak· 1 shared A. S. Perelson· 1 shared A. Shanker· 1 shared A. Vandevender· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersPhysiology

I. Scott

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Quantification of heterogeneity in human CD8+ T cell responses to vaccine antigens: an HLA-guided perspective

D. C. Harris, A. Shanker, M. M. Montoya, T. R. Llewellyn, A. R. Matuszak, A. Lohar, J. Z. Kubicek Sutherland, Y. W. Li, K. Wilding, B. Mcmahon, S. Gnanakaran, R. M. Ribeiro, A. S. Perelson, c. molina-paris

The paper introduces metrics to quantify CD8+ T cell responses to vaccine antigens, considering HLA genetic variation and viral evolution, using Ebola, SARS-CoV-2, and Burkholderia pseudomallei as examples.

bioRxiv · Jul 2, 2024Immunology

TCA Cycle Dysfunction and Amino Acid Catabolism Drive Hepatic Steatosis in Mice with HFpEF

B. Mushala, M. Stoner, J. Manning, P. Bugga, N. Bhattarai, M. Sanjani, B. McMahon, A. Vandevender, S. Mullett, B. Kaufman, S. Shiva, S. Gelhaus, M. Jurczak, I. Scott

This study shows that TCA cycle dysfunction and amino acid catabolism in mice with HFpEF drive hepatic steatosis similar to human NAFLD.

bioRxiv · Jun 3, 2024 · PreprintPhysiology

GCN5L1 promotes diastolic dysfunction by inhibiting cardiac pyruvate oxidation

D. Thapa, P. Bugga, B. A. S. Mushala, J. R. Manning, M. W. Stoner, B. McMahon, X. Zeng, P. Cantrell, N. Yates, B. Xie, L. R. Edmunds, M. J. Jurczak, I. Scott

This study identifies GCN5L1 as a regulator of cardiac pyruvate oxidation, showing its role in promoting diastolic dysfunction through inhibition of PDH complex acetylation in aged obese mice.

bioRxiv · Sep 7, 2021 · PreprintPhysiology

Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes

K. E. Watters, H. Shivram, C. Fellmann, R. J. Lew, B. McMahon, J. A. Doudna

This study identifies three new potent CRISPR-Cas9 inhibitors from Staphylococcus genomes, showing they specifically block SauCas9 activity in human cells.

bioRxiv · Oct 9, 2019Biochemistry

Structural transition and antibody binding of Ebola GP and Zika E proteins from pre-fusion to fusion-initiation state

A. Lappala, W. Nishima, J. Miner, P. Fenimore, W. Fischer, P. Hraber, M. Zhang, B. McMahon, C.-S. Tung

The paper models the fusion initiation state structures of Ebola GP and Zika E proteins using computational approaches, enhancing understanding of neutralizing antibodies.

bioRxiv · Mar 20, 2018Biophysics