Author

M. J. Jurczak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 8 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 10 Approach:experimental assay· 8 Research Focus:metabolism & bioenergetics· 6 Research Focus:cell type annotation· 5 Research Focus:cell signaling & trafficking· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3

Frequent Co-Authors

B. Xie· 5 shared D. Thapa· 4 shared I. Scott· 4 shared J. R. Manning· 4 shared M. W. Stoner· 4 shared I. Sipula· 3 shared P. Bugga· 3 shared A. B. Frias· 2 shared

Activity by Year

2016-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersPhysiology

B. Xie

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Mineralocorticoid receptor-independent activation of ENaC in bile duct ligated mice

X.-P. Wang, S. M. Mutchler, R. Carrisoza-Gaytan, M. Al-bataineh, C. J. Baty, A. Vandevender, P. Srinivasan, R. J. Tan, M. J. Jurczak, L. M. Satlin, O. B. Kashlan

This study shows that bile acid elevation in liver disease activates ENaC and causes fluid retention independently of RAAS, offering new therapeutic targets.

Journal of the American Society of Nephrology · Jul 10, 2024Peer-reviewedPhysiology

Reduced acetylation of TFAM promotes bioenergetic dysfunction in the failing heart

M. Zhang, N. Feng, D. Thapa, M. W. Stoner, J. R. Manning, C. F. McTiernan, X. Yang, Z. Peng, M. J. Jurczak, D. Guimaraes, S. Shiva, B. A. Kaufman, M. N. Sack, I. Scott

This study shows that reduced GCN5L1 expression in the failing heart leads to mitochondrial dysfunction and decreased bioenergetic output.

bioRxiv · Oct 31, 2022Physiology

G-PROTEIN COUPLED RECEPTOR 19 (GPR19) KNOCKOUT MICE DISPLAY SEX-DEPENDENT METABOLIC DYSFUNCTION

B. A. S. Mushala, B. Xie, I. Sipula, M. W. Stoner, D. Thapa, J. R. Manning, P. Bugga, A. M. Vandevender, M. J. Jurczak, I. Scott

This study shows that GPR19 knockout mice exhibit sex-dependent metabolic dysfunction, with males showing glucose intolerance and liver enlargement on a high-fat diet.

bioRxiv · Oct 29, 2022Physiology

Diet-induced obese mice are resistant to improvements in cardiac function resulting from short-term adropin treatment

D. Thapa, B. Xie, B. A. Mushala, M. Zhang, J. R. Manning, P. Bugga, M. W. Stoner, M. J. Jurczak, I. Scott

This study shows that short-term adropin treatment does not improve cardiac function in diet-induced obese mice, but reduces inhibitory phosphorylation of pyruvate dehydrogenase in cardiomyocytes.

bioRxiv · Oct 15, 2021Physiology

GCN5L1 promotes diastolic dysfunction by inhibiting cardiac pyruvate oxidation

D. Thapa, P. Bugga, B. A. S. Mushala, J. R. Manning, M. W. Stoner, B. McMahon, X. Zeng, P. Cantrell, N. Yates, B. Xie, L. R. Edmunds, M. J. Jurczak, I. Scott

This study identifies GCN5L1 as a regulator of cardiac pyruvate oxidation, showing its role in promoting diastolic dysfunction through inhibition of PDH complex acetylation in aged obese mice.

bioRxiv · Sep 7, 2021 · PreprintPhysiology

A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

J. K. Corrigan, D. Ramachandran, Y. He, C. Palmer, M. J. Jurczak, B. Li, R. H. Friedline, J. K. Kim, J. J. Ramsey, L. Lantier, O. P. McGuinness, A. S. Banks, Mouse Metabolic Phenotyping Center Energy Balance Working Group

This study analyzes indirect calorimetry data from thousands of mice to identify sources of metabolic variation and provides guidelines for designing and reporting metabolic experiments.

eLife · May 1, 2020Peer-reviewedPhysiology

Blimp-1 in adipose resident Tregs controls adipocyte beiging and obesity

L. Y. Beppu, X. Qu, G. J. Marrero, A. N. Fooks, A. B. Frias, K. E. Helfrich, I. Sipula, B. Xie, S. C. Watkins, A. C. Poholek, M. J. Jurczak, L. M. D'Cruz

This study shows that Blimp-1 in adipose Tregs suppresses IL-10, reducing beiging and increasing obesity risk, while its ablation improves insulin sensitivity and reduces weight in mice.

bioRxiv · Dec 14, 2019 · PreprintImmunology

The transcriptional regulator Id2 is critical for adipose-resident regulatory T cell differentiation, survival and function

A. B. Frias, E. J. Hyzny, H. M. Buechel, L. Beppu, B. Xie, M. J. Jurczak, L. M. D'Cruz

This study shows that Id2 is essential for the differentiation, survival, and function of adipose-resident regulatory T cells, and its loss leads to systemic inflammation and metabolic issues.

bioRxiv · Mar 27, 2019Immunology

Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance

B. A. Kaufman, F. Belmonte, N. Dedousis, I. Sipula, N. Desai, A. Singhi, y. chu, Y. Zhang, S. Bannwarth, V. Paquis-Flucklinger, L. Harrington, R. M. O'Doherty, M. J. Jurczak

This study shows that PIF1 helicase deficiency in female mice on a Western diet leads to increased weight gain but not inflammation or reduced glucose clearance.

bioRxiv · Aug 16, 2018Physiology

Adipocyte Jak2 Mediates Growth Hormone-Induced Hepatic Insulin Resistance

K. Corbit, J. P. G. Camporez, J. L. Tran, C. G. Wilson, D. Lowe, S. Nordstrom, K. Ganeshan, R. J. Perry, G. Schulman, M. J. Jurczak, E. Weiss

This study shows that adipocyte Jak2 mediates GH-induced hepatic insulin resistance through an adipose-dependent mechanism.

bioRxiv · Sep 20, 2016Physiology