A unique mechanism explaining the outstanding performance of a newly discovered doxycycline riboswitch
Janis Hoetzel, Andreas Walbrun, M. Schäfer, T. Wang, Asger Givskov Jørgensen, K. Stamatakis, Vincent J. Gunawan, O. Becker, L. Reichardt, Leon Boettger, Robin Werner Bruckhoff, Jørgen Kjems, Josef Wachtveitl, Matthias Rief, Beatrix Suess
The paper identifies a doxycycline-binding aptamer with exceptional regulatory properties in yeast and human cells, revealing a unique structural mechanism and validating its effectiveness through experimental methods.
bioRxiv · Nov 11, 2025 · PreprintMolecular Biology