Beatrix Suess

A unique mechanism explaining the outstanding performance of a newly discovered doxycycline riboswitch

The paper identifies a doxycycline-binding aptamer with exceptional regulatory properties in yeast and human cells, revealing a unique structural mechanism and validating its effectiveness through experimental methods.

NAND Hybrid Riboswitch Design by Deep Batch Bayesian Optimization

This study designs hybrid riboswitches in yeast to emulate Boolean NAND logic using machine learning-based Bayesian optimization.

Ultrahigh-throughput discovery of modified aptamers as specific and potent enzyme inhibitors

The paper introduces an ultrahigh-throughput strategy to discover modified aptamers as specific and potent enzyme inhibitors, demonstrating its effectiveness with an inhibitor of SPM-1.

Cell-free prototyping of AND-logic gates based on heterogeneous RNA activators

This study designs AND-logic gates using RNA components and tests them in vitro and in vivo, showing comparable performance to protein circuits.