Antibiotic acyldepsipeptides stimulate the Streptomyces Clp-ATPase/ClpP complex for accelerated proteolysis
L. Reinhardt, D. Thomy, M. Lakemeyer, J. Ortega, S. A. Sieber, P. Sass, H. Broetz-Oesterhelt
This paper identifies the composition of the Streptomyces Clp protease complex and reveals a new mechanism by which ADEP antibiotics accelerate proteolysis by binding to ClpP1 and Clp-ATPases.
bioRxiv · May 13, 2022Microbiology