Author

J. Ortega

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Animal Behavior & Cognition· 2 Immunology· 2 Biochemistry· 1 Biophysics· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 3 Assay:proteomics· 3 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

A. Strandburg-Peshkin· 2 shared B. T. Hirsch· 2 shared E. M. Grout· 2 shared M. C. Crofoot· 2 shared P. Minasandra· 2 shared A. Aroumougame· 1 shared A. Drakaki· 1 shared A. Guarne· 1 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersAnimal Behavior & Cognition

A. Strandburg-Peshkin

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Behavioral sequences across multiple animal species in the wild share common structural features

P. Minasandra, E. M. Grout, K. Brock, M. C. Crofoot, V. Demartsev, A. S. Gersick, B. T. Hirsch, K. E. Holekamp, L. Johnson-Ulrich, A. Nayak, J. Ortega, M. A. Roch, E. D. Strauss, A. Strandburg-Peshkin

The paper analyzes behavioral sequences in three wild mammal species and finds consistent structural patterns across all species, individuals, and behavioral states.

bioRxiv · Jan 20, 2024Animal Behavior & Cognition

Whole group tracking reveals that relatedness drives consistent subgrouping patterns in white-nosed coatis

E. M. Grout, J. Ortega, P. Minasandra, M. J. Quin, M. C. Crofoot, A. Strandburg-Peshkin, B. T. Hirsch

The study tracks GPS movements of white-nosed coatis to show that genetic relatedness, not physiological similarity, drives consistent subgrouping patterns in social groups.

bioRxiv · Dec 14, 2023Animal Behavior & Cognition

Clonally-Expanded, Thyrotoxic Autoimmune Mediator CD8+ T cells Driven by IL21 Contribute to Checkpoint Inhibitor Thyroiditis

M. G. Lechner, Z. Zhou, A. T. Hoang, N. Huang, J. Ortega, L. N. Scott, H.-C. Chen, A. Y. Patel, R. Y. Tafti, K. Kim, W. Hugo, P. Famini, A. Drakaki, A. Ribas, T. E. Angell, M. A. Su

The paper identifies clonally expanded CD8+ T cells driven by IL21 in ICI-thyroiditis using scRNA-seq and validates their role in thyroid inflammation.

bioRxiv · Dec 18, 2022 · PreprintImmunology

Development of novel cytoprotective small compounds inhibiting mitochondria-dependent apoptosis

S. Matsuyama, M. Matsuyama, J. Ortega, Y. Fedorov, J. Scott-McKean, J. Muller-Greven, M. Buck, D. Adams, B. Jastrzebska, W. Greenlee

The paper identifies and develops M109S, a small molecule that inhibits mitochondria-dependent apoptosis in various cell types and models.

bioRxiv · Oct 12, 2022 · PreprintCell Biology

KsgA facilitates ribosomal small subunit maturation by proofreading a key structural lesion

J. Sun, L. Kinman, D. Jahagirdar, J. Ortega, J. H. Davis

The paper identifies KsgA's role in ribosome assembly by using cryo-EM and machine learning to show it proofreads and disassembles immature ribosomal subunits, improving assembly fidelity.

bioRxiv · Jul 13, 2022Biochemistry

Antibiotic acyldepsipeptides stimulate the Streptomyces Clp-ATPase/ClpP complex for accelerated proteolysis

L. Reinhardt, D. Thomy, M. Lakemeyer, J. Ortega, S. A. Sieber, P. Sass, H. Broetz-Oesterhelt

This paper identifies the composition of the Streptomyces Clp protease complex and reveals a new mechanism by which ADEP antibiotics accelerate proteolysis by binding to ClpP1 and Clp-ATPases.

bioRxiv · May 13, 2022Microbiology

Structural basis for DNA targeting by the Tn7 transposon

Y. Shen, J. Gomez-Blanco, M. T. Petassi, J. E. Peters, J. Ortega, A. Guarne

This study reveals the structural mechanism of Tn7 transposon target-site selection using cryo-EM, showing how TnsC distinguishes target DNA and prevents reinsertion.

bioRxiv · May 24, 2021Biophysics

Non-parallel morphological divergence following colonization of a new host plant

K. J. Nilsson, J. Ortega, M. Friberg, A. Runemark

The paper investigates morphological divergence in peacock flies after host plant colonization, finding low and variable divergence with only one trait consistently different.

bioRxiv · Mar 30, 2021Evolutionary Biology

NBS1-CtIP-Mediated DNA End Resection Regulates cGAS Binding to Micronuclei

S. Abdisalaam, S. Mukherjee, S. Bhattacharya, D. Sinha, S. Kumari, H. A. Sadek, J. Ortega, G.-M. Li, A. Aroumougame

The paper shows NBS1-CtIP-mediated DNA end resection prevents cGAS from binding to micronuclei by modifying chromatin architecture.

bioRxiv · Jul 27, 2020 · PreprintImmunology