Author

H. Broetz-Oesterhelt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:bacteria (other)· 2 Assay:proteomics· 2 Assay:ATAC-seq· 1 Approach:biophysical modeling· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Esser· 1 shared B. Babczyk· 1 shared C. Mayer· 1 shared D. A. Mitchell· 1 shared D. Hoeroempoeli· 1 shared D. Matzner· 1 shared D. Menche· 1 shared D. T. Nguyen· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperMicrobiology

A. Esser

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Bioinformatics-Guided Discovery of Biaryl-Tailored Lasso Peptides

H. Saad, T. Majer, K. Bhattarai, S. Lampe, D. T. Nguyen, M. Kramer, J. Straetener, H. Broetz-Oesterhelt, D. A. Mitchell, H. Gross

The paper discovers and characterizes two novel biaryl-containing lasso peptides, revealing new structural modifications and biosynthetic enzymes.

bioRxiv · Mar 6, 2023 · PreprintBiochemistry

Metabolization of alpha-D-carba-glucosamine in vivo generates antimetabolites of cell wall precursors

M. Mund, S. Friz, A. Esser, D. Matzner, B. Babczyk, D. Menche, H. Broetz-Oesterhelt, C. Mayer, G. Mayer

This study shows that CGlcN is metabolized into carba-metabolites that inhibit bacterial cell wall synthesis, revealing a new antimetabolite mechanism of action.

bioRxiv · Feb 8, 2023 · PreprintMicrobiology

Uptake of aminoglycosides through outer membrane porins in Escherichia coli

E. Paul, I. Ghai, D. Hoeroempoeli, H. Broetz-Oesterhelt, M. Winterhalter, J. A. Bafna

The paper quantifies and compares the passive transport of three aminoglycosides through different porins in E. coli, revealing varying permeation rates and confirming their relevance to antibiotic potency.

bioRxiv · Sep 5, 2022 · PreprintBiophysics

Antibiotic acyldepsipeptides stimulate the Streptomyces Clp-ATPase/ClpP complex for accelerated proteolysis

L. Reinhardt, D. Thomy, M. Lakemeyer, J. Ortega, S. A. Sieber, P. Sass, H. Broetz-Oesterhelt

This paper identifies the composition of the Streptomyces Clp protease complex and reveals a new mechanism by which ADEP antibiotics accelerate proteolysis by binding to ClpP1 and Clp-ATPases.

bioRxiv · May 13, 2022Microbiology