Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation reveals multisite regulation of surface expression and gating
M. Lorenzini, S. Burel, A. Lesage, E. Wagner, C. Charriere, P.-M. Chevillard, B. Evrard, D. Maloney, K. M. Ruff, R. V. Pappu, S. Wagner, J. M. Nerbonne, J. R. Silva, R. R. Townsend, L. S. Maier, C. Marionneau
The paper identifies 42 phosphorylation sites on NaV1.5 channels in mouse hearts and shows their roles in regulating channel expression and gating.
bioRxiv · Apr 29, 2020Physiology