Cryo-EM Structure of a Human LECT2 Amyloid Fibril Reveals a Network of Polar Ladders at its Core
L. S. Richards, M. D. Flores, S. Zink, N. A. Schibrowsky, M. R. Sawaya, J. A. Rodriguez
This paper determines the cryo-EM structure of human LECT2 amyloid fibrils, revealing a tightly packed core stabilized by polar residues and hydrophobic contacts.
bioRxiv · Feb 8, 2023Biochemistry