J. A. Rodriguez

Exosomal microRNA signature from plasma-derived extracellular vesicles in gastric cancer

The paper identifies a nine-miRNA signature from plasma-derived exosomes to classify benign vs. malignant gastric diseases and detects 15 differentially expressed miRNAs across cancer stages.

Cryo-EM Structure of a Human LECT2 Amyloid Fibril Reveals a Network of Polar Ladders at its Core

This paper determines the cryo-EM structure of human LECT2 amyloid fibrils, revealing a tightly packed core stabilized by polar residues and hydrophobic contacts.

Structure of a reversible amyloid fibril formed by the CPEB3 prion-like domain reveals a core sequence involved in translational regulation

This study identifies an amyloidogenic segment in CPEB3's prion domain that is critical for its function in translational regulation and long-term memory.

Lis1 relieves cytoplasmic dynein-1 auto-inhibition by acting as a molecular wedge

The paper presents a structure showing Lis1 relieves dynein-1 auto-inhibition by acting as a molecular wedge, revealing its role in dynein activation.

Autocrine Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts

The paper identifies Sfrp1 as an autocrine inhibitor of fibroblast invasion during lung fibrosis by analyzing fibroblast states and signaling pathways in mouse lung regeneration.

Fragment-based ab initio phasing of peptidic nanocrystals by MicroED

This paper introduces a fragment-based method for de novo structure determination of peptidic nanocrystals using MicroED, enabling the solution of previously intractable structures.

Atomic structures determined from digitally defined nanocrystalline regions

This paper introduces a method to determine atomic structures from digitally defined regions of nanocrystals using scanning nanobeam electron diffraction.

LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is altered in Townes-Brocks Syndrome

The paper identifies LUZP1 as a regulator of primary cilia and actin cytoskeleton, showing its role in Townes-Brocks Syndrome through interactions with SALL1 and effects on ciliogenesis and Sonic Hedgehog signaling.

Homochiral and racemic MicroED structures of a peptide from the ice nucleation protein InaZ

The paper determines homochiral and racemic structures of a peptide from InaZ using MicroED, revealing amyloid-like protofibrils with distinct chiral arrangements.