Author

M. D. Flores

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Assay:electronic health records· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. A. Rodriguez· 3 shared M. R. Sawaya· 3 shared C.-T. Zee· 2 shared S. Zink· 2 shared A. Saucedo· 1 shared C. Glynn· 1 shared C. Millan· 1 shared D. R. Boyer· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiochemistry

J. A. Rodriguez

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3 papers

Recent·Most cited

Cryo-EM Structure of a Human LECT2 Amyloid Fibril Reveals a Network of Polar Ladders at its Core

L. S. Richards, M. D. Flores, S. Zink, N. A. Schibrowsky, M. R. Sawaya, J. A. Rodriguez

This paper determines the cryo-EM structure of human LECT2 amyloid fibrils, revealing a tightly packed core stabilized by polar residues and hydrophobic contacts.

bioRxiv · Feb 8, 2023Biochemistry

Structure of a reversible amyloid fibril formed by the CPEB3 prion-like domain reveals a core sequence involved in translational regulation

M. D. Flores, M. R. Sawaya, D. R. Boyer, S. Zink, S. Tovmasyan, A. Saucedo, C.-T. Zee, J. Cardenas, L. Fioriti, J. A. Rodriguez

This study identifies an amyloidogenic segment in CPEB3's prion domain that is critical for its function in translational regulation and long-term memory.

bioRxiv · Dec 7, 2022 · PreprintBiochemistry

Fragment-based ab initio phasing of peptidic nanocrystals by MicroED

L. Richards, M. D. Flores, C. Millan, C.-T. Zee, C. Glynn, M. R. Sawaya, M. Gallagher-Jones, R. Borges, I. Uson, J. A. Rodriguez

This paper introduces a fragment-based method for de novo structure determination of peptidic nanocrystals using MicroED, enabling the solution of previously intractable structures.

bioRxiv · Sep 13, 2021Biochemistry