Activation of the Integrated Stress Response overcomes multidrug resistance in FBXW7-deficient cells
L. Sanchez-Burgos, B. Navarro-Gonzalez, S. Garcia-Martin, H. Tejero, M. E. Anton, F. Al-Shahrour, O. Fernandez-Capetillo
This study shows that FBXW7 deficiency causes multidrug resistance, which can be overcome by targeting mitochondria and activating the Integrated Stress Response.
bioRxiv · Jan 17, 2022 · PreprintCancer Biology