Author

F. Al-Shahrour

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. E. Anton· 2 shared O. Fernandez-Capetillo· 2 shared A. Culhane· 1 shared A. De Nicolo· 1 shared A. Edsjo· 1 shared A. Flobak· 1 shared A. Patocs· 1 shared A. Valencia· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

M. E. Anton

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The Minimal Dataset for Cancer of the 1+Million Genomes Initiative

M. Riba, C. Sala, A. Culhane, A. Flobak, A. Patocs, K. Boye, K. Plevova, S. Pospisilova, G. Gandolfi, M. Morelli, G. Bucci, A. Edsjo, U. Lassen, F. Al-Shahrour, N. Lopez-Bigas, , G. Tonon

The paper develops a standardized data model for cancer genomics to enable interoperable data sharing across countries.

bioRxiv · Oct 7, 2023 · PreprintCancer Biology

The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

S. Chaib, J. A. Lopez-Dominguez, M. Lalinde, N. Prats, I. Marin, K. Meyer, M. I. Munoz, M. Aguilera, L. Mateo, C. S.-O. Attolini, S. Llanos, M. Escorihuela, S. Perez-Ramos, F. Al-Shahrour, T. P. Cash, , M. Serrano

This study identifies PD-L2 as a marker of therapy-induced senescent cells that suppress chemotherapy efficacy, showing PD-L2 blockade enhances tumour remission in mice.

bioRxiv · Nov 4, 2022 · PreprintCancer Biology

PD-L1ATTAC mice reveal the potential of targeting PD-L1 expressing cells in cancer therapy

E. Fueyo-Marcos, C. Fustero-Torre, G. Lopez, M. E. Anton, F. Al-Shahrour, O. Fernandez-Capetillo, M. Murga

The paper develops PD-L1ATTAC mice to study PD-L1-expressing cells' role in cancer and immunity, finding their elimination enhances antitumor immunity and worsens septic responses.

bioRxiv · Jul 22, 2022 · PreprintCancer Biology

Activation of the Integrated Stress Response overcomes multidrug resistance in FBXW7-deficient cells

L. Sanchez-Burgos, B. Navarro-Gonzalez, S. Garcia-Martin, H. Tejero, M. E. Anton, F. Al-Shahrour, O. Fernandez-Capetillo

This study shows that FBXW7 deficiency causes multidrug resistance, which can be overcome by targeting mitochondria and activating the Integrated Stress Response.

bioRxiv · Jan 17, 2022 · PreprintCancer Biology

Global transcriptomic profiling of the bone marrow stromal microenvironment during postnatal development, aging and inflammation

P. M. Helbling, E. Pineiro-Yanez, R. Gerosa, S. Boettcher, F. Al-Shahrour, M. G. Manz, C. Nombela-Arrieta

This study profiles the transcriptome of bone marrow stromal subsets across development, aging, and inflammation in mice, revealing dynamic transcriptional changes and their link to hematopoietic function.

bioRxiv · Aug 9, 2019Immunology