O. Fernandez-Capetillo

Discovery of a novel inhibitor of macropinocytosis with antiviral activity

This study identifies virapinib, a novel inhibitor of macropinocytosis that blocks viral entry by SARS-CoV-2, Monkeypox virus, and TBEV without host cell toxicity.

PD-L1ATTAC mice reveal the potential of targeting PD-L1 expressing cells in cancer therapy

The paper develops PD-L1ATTAC mice to study PD-L1-expressing cells' role in cancer and immunity, finding their elimination enhances antitumor immunity and worsens septic responses.

Activation of the Integrated Stress Response overcomes multidrug resistance in FBXW7-deficient cells

This study shows that FBXW7 deficiency causes multidrug resistance, which can be overcome by targeting mitochondria and activating the Integrated Stress Response.

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo

A bispecific nanobody neutralizes SARS-CoV-2 and its variant B.1.351 by inducing spike trimer-dimers that prevent ACE2 binding.

Supraphysiological protection from replication stress does not extend mammalian lifespan

This study shows that enhancing replication stress protection in mice does not increase lifespan, suggesting replication stress is not a major driver of normal aging.

ATR expands embryonic stem cell fate potential in response to replication stress

This study identifies an ATR-CHK1 pathway in ESCs that enhances fate potential by inducing 2C-like gene expression in response to replication stress.

Estrogen deprivation triggers an immunosuppressive phenotype in breast cancer cells

This study shows that estrogen deprivation in ER-positive breast cancer cells increases PD-L1 expression and triggers an immunosuppressive program, leading to resistance against T-cell killing.

ATR Is Required To Complete Meiotic Recombination In Mice

This study shows ATR is essential for meiotic recombination and prophase completion in mice by promoting RAD51/DMC1 assembly and synapsis.