Combinatorial G x G x E CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transport
X. Shi, B. Reinstadler, H. Shah, T.-L. To, K. Byrne, L. Summer, S. E. Calvo, O. Goldberger, J. G. Doench, V. K. Mootha, H. Shen
The paper uses CRISPR screening to identify gene-by-gene and gene-by-environment interactions among mitochondrial transporters, revealing SLC25A39's role in mitochondrial glutathione transport.
bioRxiv · Sep 22, 2021 · PreprintCell Biology