V. K. Mootha

METTL17 is an Fe-S cluster checkpoint for mitochondrial translation

The paper identifies METTL17 as an Fe-S cluster checkpoint that regulates mitochondrial translation and bioenergetics in the absence of frataxin.

A natural fusion of flavodiiron, rubredoxin, and NADH:rubredoxin oxidoreductase domains is the highly efficient water-forming oxidase of T. vaginalis

This study identifies a unique fusion protein in T. vaginalis that efficiently catalyzes oxygen reduction to water using NADH, providing structural and functional insights into its redox system.

Combinatorial G x G x E CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transport

The paper uses CRISPR screening to identify gene-by-gene and gene-by-environment interactions among mitochondrial transporters, revealing SLC25A39's role in mitochondrial glutathione transport.

Salvage of Ribose from Uridine or RNA Supports Glycolysis when Glucose is Limiting

The paper identifies a pathway called uridinolysis that allows cells to use uridine and RNA-derived ribose to support glycolysis when glucose is limiting.

Structural insights into the Ca 2+-dependent gating of the human mitochondrial calcium uniporter

This study presents EM structures of the human mitochondrial calcium uniporter holocomplex with and without Ca2+, showing how Ca2+ affects its assembly and channel pore blockage.

Molecular basis of EMRE-dependence of the human mitochondrial calcium uniporter

The paper identifies an EMRE-dependence domain in human MCU that enables calcium conductance, revealing how EMRE stabilizes this domain for channel function.