Author

K. Byrne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:machine learning (classical)· 1 Organism:plant (other)· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Ahrens· 1 shared A. Boettcher· 1 shared A. Dias Costa· 1 shared A. G. Cino-Ozuna· 1 shared B. M. Wolpin· 1 shared B. Reinstadler· 1 shared B. Schultz· 1 shared B. Tate· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperImmunology

A. Ahrens

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Machine learning links T cell function and spatial localization to neoadjuvant immunotherapy and clinical outcome in pancreatic cancer

K. E. Blise, S. Sivagnanam, C. B. Betts, K. Betre, N. Kirchberger, B. Tate, E. E. Furth, A. Dias Costa, J. A. Nowak, B. M. Wolpin, R. H. Vonderheide, J. Goecks, L. M. Coussens, K. Byrne

This study uses machine learning to analyze spatial proteomic data from pancreatic cancer patients, linking T cell function and localization to neoadjuvant CD40 therapy and clinical outcomes.

bioRxiv · Oct 20, 2023Cancer Biology

Combinatorial G x G x E CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transport

X. Shi, B. Reinstadler, H. Shah, T.-L. To, K. Byrne, L. Summer, S. E. Calvo, O. Goldberger, J. G. Doench, V. K. Mootha, H. Shen

The paper uses CRISPR screening to identify gene-by-gene and gene-by-environment interactions among mitochondrial transporters, revealing SLC25A39's role in mitochondrial glutathione transport.

bioRxiv · Sep 22, 2021 · PreprintCell Biology

Novel engraftment and T cell differentiation of human hematopoietic cells in Art-/- IL2RG-/ SCID pigs

A. Boettcher, Y. Li, A. Ahrens, M. Kiupel, K. Byrne, C. Loving, A. G. Cino-Ozuna, J. Wiarda, M. Adur, B. Schultz, J. Swanson, E. Snella, C.-S. Ho, S. Charley, Z. Kiefer, , C. Tuggle

The paper generates a T-B-NK-SCID pig model via CRISPR/Cas9 and demonstrates successful human hematopoietic cell engraftment in blood and lymphoid organs after in utero injection.

bioRxiv · May 2, 2019 · PreprintImmunology