Constrained evolutionary paths to macrolide resistance in a Neisseria commensal converge on ribosomal genes through sequence duplication
J. C. Raisman, M. A. Fiore, L. Tomin, J. K. Adjei, V. Aswad, J. Chu, C. J. Domondon, B. A. Donahue, C. A. Masciotti, C. G. McGrath, J. Melita, P. A. Podbielski, M. R. Schreiner, L. J. Trumpore, P. C. Wengert, , C. B. Wadsworth
This study identifies azithromycin resistance mutations in Neisseria elongata through experimental evolution, showing convergence on ribosomal genes via duplication and assessing their potential for horizontal transfer to N. gonorrhoeae.
bioRxiv · Apr 5, 2021Microbiology