Author

A. O. Hudson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biophysics· 2 Evolutionary Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Approach:machine learning (classical)· 2 Assay:proteomics· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

C. B. Wadsworth· 2 shared G. A. Babbitt· 2 shared J. C. Raisman· 2 shared M. A. Fiore· 2 shared M. L. Lynch· 2 shared A. C. Muscroft-Taylor· 1 shared A. J. Board· 1 shared A. Parthasarathy· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

C. B. Wadsworth

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Author profile →

7 papers

Recent·Most cited

Genetic drift and genome reduction in the plant pathogen Candidatus Liberibacter solanacearum shapes a new enzyme in lysine biosynthesis.

J. M. Gilkes, R. A. Frampton, A. J. Board, A. O. Hudson, T. Price, D. L. Crittenden, A. C. Muscroft-Taylor, C. R. Sheen, G. R. Smith, R. C. J. Dobson

This study examines how genome reduction and genetic drift in Candidatus Liberibacter solanacearum affect the function of its dihydrodipicolinate synthase, revealing structural and kinetic changes in the enzyme.

bioRxiv · Apr 17, 2023 · PreprintEvolutionary Biology

Constrained evolutionary paths to macrolide resistance in a Neisseria commensal converge on ribosomal genes through sequence duplication

J. C. Raisman, M. A. Fiore, L. Tomin, J. K. Adjei, V. Aswad, J. Chu, C. J. Domondon, B. A. Donahue, C. A. Masciotti, C. G. McGrath, J. Melita, P. A. Podbielski, M. R. Schreiner, L. J. Trumpore, P. C. Wengert, , C. B. Wadsworth

This study identifies azithromycin resistance mutations in Neisseria elongata through experimental evolution, showing convergence on ribosomal genes via duplication and assessing their potential for horizontal transfer to N. gonorrhoeae.

bioRxiv · Apr 5, 2021Microbiology

Functional binding dynamics relevant to the evolution of zoonotic spillovers in endemic and emergent Betacoronavirus strains

P. Rynkiewicz, G. A. Babbitt, F. Cui, A. O. Hudson, M. L. Lynch

The paper uses machine learning on molecular dynamics simulations to analyze conserved functional binding dynamics between Betacoronavirus strains and ACE2/CD26, identifying pre-adapted regions linked to zoonotic spillovers.

bioRxiv · Sep 11, 2020 · PreprintBiophysics

Exploration of the Neisseria resistome reveals resistance mechanisms in commensals that may be acquired by N. gonorrhoeae through horizontal gene transfer

M. A. Fiore, J. C. Raisman, N. H. Wong, A. O. Hudson, C. B. Wadsworth

The paper identifies resistance mutations in non-pathogenic Neisseria that could be transferred to N. gonorrhoeae, using MIC testing and whole genome sequencing.

bioRxiv · Jul 30, 2020Microbiology

Function and evolution of B-Raf loop dynamics relevant to cancer recurrence under drug inhibition

G. A. Babbitt, M. L. Lynch, M. McCoy, E. P. Fokoue, A. O. Hudson

This study uses molecular dynamics simulations and machine learning to analyze how B-Raf loop dynamics change under drug inhibition and genetic mutations, showing that ATP competitive inhibitors reduce hyperactivation risks.

bioRxiv · Jan 13, 2020Biophysics

Insight into the resistome and quorum sensing system of a divergent Acinetobacter pittii isolate from an untouched site of the Lechuguilla Cave

H. M. Gan, P. Wengert, H. Barton, A. O. Hudson, M. Savka

The paper reports the genome sequence of an Acinetobacter pittii isolate from Lechuguilla Cave, identifying antibiotic resistance genes and quorum sensing capabilities in a pristine environment.

bioRxiv · Nov 27, 2019Microbiology

The gene annotated by the locus tag At3g08860 encodes a β-alanine/L-alanine aminotransferase in Arabidopsis thaliana

A. Parthasarathy, F. C. Savka, A. O. Hudson

This study identifies the function of the Arabidopsis thaliana aminotransferase gene At3g08860, showing it encodes a β-alanine/L-alanine aminotransferase and complements E. coli mutants.

bioRxiv · Mar 12, 2019Plant Biology