Author

C. B. Wadsworth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

A. O. Hudson· 2 shared J. C. Raisman· 2 shared M. A. Fiore· 2 shared Y. H. Grad· 2 shared B. A. Donahue· 1 shared B. J. Arnold· 1 shared B. S. Coates· 1 shared C. A. Masciotti· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersMicrobiology

A. O. Hudson

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Rolling the evolutionary dice: Neisseria commensals as proxies for elucidating the underpinnings of antibiotic resistance mechanisms and evolution in human pathogens

K. M. Frost, S. L. Charron-Smith, T. C. Cotsonas, D. C. Dimartino, R. C. Eisenhart, E. T. Everingham, E. C. Holland, K. Imtiaz, C. J. Kornowicz, L. E. Lenhard, L. H. Lynch, N. P. Moore, K. Phadke, M. L. Reed, S. R. Smith, , C. B. Wadsworth

This study uses in vitro evolution of commensal Neisseria species to investigate resistance evolution to azithromycin and penicillin, finding convergent mutations in key resistance mechanisms.

bioRxiv · Sep 26, 2023 · PreprintMicrobiology

Constrained evolutionary paths to macrolide resistance in a Neisseria commensal converge on ribosomal genes through sequence duplication

J. C. Raisman, M. A. Fiore, L. Tomin, J. K. Adjei, V. Aswad, J. Chu, C. J. Domondon, B. A. Donahue, C. A. Masciotti, C. G. McGrath, J. Melita, P. A. Podbielski, M. R. Schreiner, L. J. Trumpore, P. C. Wengert, , C. B. Wadsworth

This study identifies azithromycin resistance mutations in Neisseria elongata through experimental evolution, showing convergence on ribosomal genes via duplication and assessing their potential for horizontal transfer to N. gonorrhoeae.

bioRxiv · Apr 5, 2021Microbiology

Exploration of the Neisseria resistome reveals resistance mechanisms in commensals that may be acquired by N. gonorrhoeae through horizontal gene transfer

M. A. Fiore, J. C. Raisman, N. H. Wong, A. O. Hudson, C. B. Wadsworth

The paper identifies resistance mutations in non-pathogenic Neisseria that could be transferred to N. gonorrhoeae, using MIC testing and whole genome sequencing.

bioRxiv · Jul 30, 2020Microbiology

Genomic basis of circannual rhythm in the European corn borer moth

G. M. Kozak, C. B. Wadsworth, S. C. Kahne, S. M. Bogdanowicz, R. G. Harrison, B. S. Coates, E. B. Dopman

The paper identifies genomic variation linked to circannual rhythm differences in the European corn borer moth, showing interactions between circadian clock genes per and Pdfr.

bioRxiv · May 9, 2019Evolutionary Biology

Impact of population structure in the design of RNA-based diagnostics for antibiotic resistance in Neisseria gonorrhoeae

C. B. Wadsworth, M. R. A. Sater, R. P. Bhattacharyya, Y. H. Grad

This study evaluates RNA-based diagnostics for antibiotic resistance in Neisseria gonorrhoeae, finding that population structure affects transcriptional responses and identifying candidate transcripts for azithromycin resistance.

bioRxiv · Jan 31, 2019Microbiology

Azithromycin resistance through interspecific acquisition of an epistasis dependent efflux pump component and transcriptional regulator in Neisseria gonorrhoeae

C. B. Wadsworth, B. J. Arnold, M. R. Sater, Y. H. Grad

The paper identifies epistatic interactions between mtrD and promoter mutations in Neisseria gonorrhoeae that contribute to azithromycin resistance through horizontal gene transfer.

bioRxiv · Apr 27, 2018Microbiology