Author

L. Torella

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

G. Gonzalez-Aseguinolaza· 2 shared A. Aldaz· 1 shared A. Garcia-Torralba· 1 shared A. Montfort· 1 shared A. Vales· 1 shared B. Segui· 1 shared C. Olague· 1 shared C. Usai· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPathology

G. Gonzalez-Aseguinolaza

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2 papers

Recent·Most cited

Protective Role of RIPK1 Scaffolding against HDV-Induced Hepatocyte cell death and the Significance of Cytokines in Mice

G. Camps, S. Maestro, L. Torella, C. Usai, A. Aldaz, C. Olague, A. Vales, A. Montfort, B. Segui, L. Suarez, R. Aldabe, G. Gonzalez-Aseguinolaza

This study investigates the role of RIPK1 scaffolding in protecting against HDV-induced hepatocyte death and highlights the involvement of cytokines like TNF- and type-I IFN in liver damage.

bioRxiv · Oct 15, 2023Pathology

In vitro and In vivo Genetic Disease Modelling via NHEJ precise deletions using CRISPR/Cas9

S. Lopez-Manzaneda, I. Ojeda-Perez, N. Zabaleta, A. Garcia-Torralba, O. Alberquilla, R. Torres, R. Sanchez-Dominguez, L. Torella, E. Olivier, J. Mountford, J. C. Ramirez, J. A. Bueren, G. Gonzalez-Aseguinolaza, J. C. Segovia

The paper demonstrates that using two guideRNAs at optimal distance and orientation with CRISPR/Cas9 enables precise deletions for creating genetically reproducible disease models in human and mouse cells.

bioRxiv · Mar 25, 2020Bioengineering