L. Truong

Epigenetic control of multiple genes with a single lentiviral vector encoding transcriptional repressors fused to compact zinc finger arrays

This paper develops a lentiviral system to simultaneously repress multiple genes using zinc finger repressors, showing efficient and long-term gene silencing without DNA editing.

Identification and structural characterization of small-molecule inhibitors of PINK1

This study identifies and characterizes small-molecule inhibitors of PINK1, revealing their mechanism of action and potential for developing PD therapeutics.

Deep autoencoder-based behavioral pattern recognition outperforms standard statistical methods in high-dimensional zebrafish studies

This paper demonstrates that deep autoencoders outperform traditional statistical methods in detecting abnormal behavior in zebrafish exposed to toxicants.

Nitrate and nitrite exposure increases anxiety-like behavior and alters brain metabolomic profile in zebrafish

This study shows that nitrate and nitrite exposure in zebrafish increases anxiety-like behavior and alters brain metabolites, including reduced GABA and glutamine, without affecting overall health.