Author

N. Croteau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

J.-F. Trempe· 4 shared E. A. Fon· 2 shared S. Rasool· 2 shared S. Veyron· 2 shared T. M. Durcan· 2 shared A. A. Z. Khalifa· 1 shared C. Black· 1 shared D. Pelletier· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersBiochemistry

J.-F. Trempe

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4 papers

Recent·Most cited

Identification and structural characterization of small-molecule inhibitors of PINK1

S. Rasool, T. Shomali, L. Truong, N. Croteau, S. Veyron, J.-F. Trempe

This study identifies and characterizes small-molecule inhibitors of PINK1, revealing their mechanism of action and potential for developing PD therapeutics.

bioRxiv · Oct 2, 2023Biochemistry

Structure-based design and characterization of Parkin activating mutations

J.-F. Trempe, M. U. Stevens, N. Croteau, M. A. Eldeeb, Z. W. Zeng, R. Toth, T. M. Durcan, W. Springer, E. A. Fon, M. M. K. Muqit

The paper identifies three Parkin activating mutations that rescue mitophagy defects in cell-based studies, suggesting therapeutic potential for Parkinson's disease.

bioRxiv · Feb 22, 2022Biochemistry

Selective localization of Mfn2 near PINK1 enable its preferential ubiquitination by Parkin on mitochondria

M. Vranas, Y. Lu, S. Rasool, N. Croteau, J. D. Krett, V. Sauve, K. Gehring, E. A. Fon, T. M. Durcan, J.-F. Trempe

The paper identifies Mfn2 as a preferred Parkin substrate due to its proximity to PINK1, which facilitates Parkin activation and ubiquitination on mitochondria.

bioRxiv · Aug 25, 2021Biochemistry

Crystal structure of human PACRG in complex with MEIG1

N. Khan, D. Pelletier, S. Veyron, N. Croteau, M. Ichikawa, C. Black, A. A. Z. Khalifa, S. Chaaban, I. Kurinov, G. Brouhard, K. H. Bui, J.-F. Trempe

The paper reports the crystal structure of human PACRG with MEIG1 and models its role in microtubule junctions, revealing interactions with tubulin and evolutionary insights.

bioRxiv · Sep 27, 2019Cell Biology